What is cyclic phosphatidic acid (cPA)?
- Phospholipids with unique cyclic phosphate structure
- Isolated, purified and structurally determined from the culture medium of a true slime mold (Physarum polycephalum)
- Bioactive substance present at low concentrations (around 0.1 μM) in higher organisms and even in human serum
- Similar in structure to lysophosphatidic acid (LPA), which causes a variety of pathologies, and inhibits autotaxin (ATX), the enzyme responsible for LPA production
- Exhibits a variety of activities (neuroprotective, anti-inflammatory, analgesic, inhibits cancer metastasis, etc.)
Structual formulas of NcPA and 2ccPA