About cPA

What is cyclic phosphatidic acid (cPA)?

  • Phospholipids with unique cyclic phosphate structure
  • Isolated, purified and structurally determined from the culture medium of a true slime mold (Physarum polycephalum)
  • Bioactive substance present at low concentrations (around 0.1 μM) in higher organisms and even in human serum
  • Similar in structure to lysophosphatidic acid (LPA), which causes a variety of pathologies, and inhibits autotaxin (ATX), the enzyme responsible for LPA production
  • Exhibits a variety of activities (neuroprotective, anti-inflammatory, analgesic, inhibits cancer metastasis, etc.)

     Structual formulas of NcPA and 2ccPA